Distribution of CD4+ T-lymphocytes levels in patients with clinical symptoms of AIDS in three West African countries
Identifieur interne : 001244 ( Main/Exploration ); précédent : 001243; suivant : 001245Distribution of CD4+ T-lymphocytes levels in patients with clinical symptoms of AIDS in three West African countries
Auteurs : Yaw Adu-Sarkodie [Ghana] ; Affoué Sangaré ; Oscar A. D Lmeida [Togo] ; Georgette D. Kanmogne [Royaume-Uni]Source :
- Journal of Clinical Virology [ 1386-6532 ] ; 1998.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Afrique de l'Ouest, Antigènes CD4 (sang), Femelle, Humains, Mâle, Numération des lymphocytes CD4, Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome d'immunodéficience acquise (immunologie), Séronégativité VIH (immunologie), Séropositivité VIH (immunologie), Test ELISA, Trousses de réactifs pour diagnostic, VIH (Virus de l'Immunodéficience Humaine) (immunologie).
- MESH :
- Wicri :
English descriptors
- KwdEn :
- AIDS, Acquired Immunodeficiency Syndrome (immunology), Adolescent, Adult, Africa, Western, Aged, Aged, 80 and over, Aids pandemic group, Aids patients, Antigens, CD4 (blood), Assay, Blood samples, CD4 Lymphocyte Count, CD4 T-lymphocyte equivalents, Cell count, Cell level, Cell levels, Clinical aids, Clinical signs, Clinical symptoms, Clinical trials, Cote, Cote abidjan, Cote patients, Diagnostic virology, Disease control, Elsevier science, Enzyme-Linked Immunosorbent Assay, Female, Ghana, Ghana cote togo, HIV, HIV (immunology), HIV Seronegativity (immunology), HIV Seropositivity (immunology), Humans, Komfo anokye teaching hospital, Lower level, Lymphocyte, Lymphocyte count, Lymphocyte levels, Male, Middle Aged, Negative patients, Negative population, Reagent Kits, Diagnostic, Seropositive patients, Standard curve, Standard deviation, Togo, Unknown viruses, Virology, West Africa, West africa, West african countries, West african population, Wkly epidemiol, World health organisation.
- MESH :
- chemical , blood : Antigens, CD4.
- geographic : Africa, Western, Reagent Kits, Diagnostic.
- immunology : Acquired Immunodeficiency Syndrome, HIV, HIV Seronegativity, HIV Seropositivity.
- Teeft :
- Adolescent, Adult, Aged, Aged, 80 and over, Aids pandemic group, Aids patients, Assay, Blood samples, CD4 Lymphocyte Count, Cell count, Cell level, Cell levels, Clinical aids, Clinical signs, Clinical symptoms, Clinical trials, Cote, Cote abidjan, Cote patients, Diagnostic virology, Disease control, Elsevier science, Enzyme-Linked Immunosorbent Assay, Female, Ghana, Ghana cote togo, Humans, Komfo anokye teaching hospital, Lower level, Lymphocyte, Lymphocyte count, Lymphocyte levels, Male, Middle Aged, Negative patients, Negative population, Seropositive patients, Standard curve, Standard deviation, Togo, Unknown viruses, Virology, West africa, West african countries, West african population, Wkly epidemiol, World health organisation.
Abstract
Objectives: To study the CD4 T-lymphocyte distribution in patients with clinical signs suggestive of AIDS in West Africa. Design and methods: Selected patients had clinical AIDS, according to the WHO clinical definition of AIDS in Africa. Serum samples were tested for the presence of HIV antibodies with two different enzyme immunoassays (EIA), and whole blood was used to determine the CD4 lymphocyte levels of each patient, using the TRAx® CD4 Test Kit. Results: In patients with AIDS, the mean CD4+ cell level was 466/μl; 34% of patients had less than 200/μl and 62.1% less than 400/μl. In patients with clinical AIDS but without HIV antibodies, the mean CD4+ cell level was 807/μl; with 4% below 200/μl and 14.7% below 400/μl. The optimal CD4+ cell cut-off between the two groups of patients (with and without antibody to HIV) was 400/μl. Conclusions: The mean CD4 cell levels of AIDS patients was more than twice the 200 CD4+ cells/μl which, alone or associated with clinical criteria is used to differentiate HIV seropositive patients with and without AIDS. A cut-off of 400 T-lymphocyte equivalents per microlitre (TLE/μl) will be more appropriate. Only 4% of the anti-HIV negative patients had <200 CD4 TLE/μl, and could be infected with unknown immunodeficiency viruses.
Url:
DOI: 10.1016/S0928-0197(98)00062-2
Affiliations:
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Kanmogne</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Division of Transfusion Medicine, East Anglia Blood Centre, Long Road, Cambridge CB2 2PT</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Clinical Virology</title><title level="j" type="abbrev">JCV</title><idno type="ISSN">1386-6532</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="173">173</biblScope><biblScope unit="page" to="181">181</biblScope></imprint><idno 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Assay</term><term>Female</term><term>Ghana</term><term>Ghana cote togo</term><term>HIV</term><term>HIV (immunology)</term><term>HIV Seronegativity (immunology)</term><term>HIV Seropositivity (immunology)</term><term>Humans</term><term>Komfo anokye teaching hospital</term><term>Lower level</term><term>Lymphocyte</term><term>Lymphocyte count</term><term>Lymphocyte levels</term><term>Male</term><term>Middle Aged</term><term>Negative patients</term><term>Negative population</term><term>Reagent Kits, Diagnostic</term><term>Seropositive patients</term><term>Standard curve</term><term>Standard deviation</term><term>Togo</term><term>Unknown viruses</term><term>Virology</term><term>West Africa</term><term>West africa</term><term>West african countries</term><term>West african population</term><term>Wkly epidemiol</term><term>World health organisation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Afrique de 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scheme="MESH" qualifier="immunology" xml:lang="en"><term>Acquired Immunodeficiency Syndrome</term><term>HIV</term><term>HIV Seronegativity</term><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes CD4</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Aids pandemic group</term><term>Aids patients</term><term>Assay</term><term>Blood samples</term><term>CD4 Lymphocyte Count</term><term>Cell count</term><term>Cell level</term><term>Cell levels</term><term>Clinical aids</term><term>Clinical signs</term><term>Clinical symptoms</term><term>Clinical trials</term><term>Cote</term><term>Cote abidjan</term><term>Cote patients</term><term>Diagnostic virology</term><term>Disease control</term><term>Elsevier science</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Ghana</term><term>Ghana cote togo</term><term>Humans</term><term>Komfo anokye teaching hospital</term><term>Lower level</term><term>Lymphocyte</term><term>Lymphocyte count</term><term>Lymphocyte levels</term><term>Male</term><term>Middle Aged</term><term>Negative patients</term><term>Negative population</term><term>Seropositive patients</term><term>Standard curve</term><term>Standard deviation</term><term>Togo</term><term>Unknown viruses</term><term>Virology</term><term>West africa</term><term>West african countries</term><term>West african population</term><term>Wkly epidemiol</term><term>World health organisation</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Afrique de l'Ouest</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Test ELISA</term><term>Togo</term><term>Trousses de réactifs pour diagnostic</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Sida</term><term>Afrique occidentale</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: To study the CD4 T-lymphocyte distribution in patients with clinical signs suggestive of AIDS in West Africa. Design and methods: Selected patients had clinical AIDS, according to the WHO clinical definition of AIDS in Africa. Serum samples were tested for the presence of HIV antibodies with two different enzyme immunoassays (EIA), and whole blood was used to determine the CD4 lymphocyte levels of each patient, using the TRAx® CD4 Test Kit. Results: In patients with AIDS, the mean CD4+ cell level was 466/μl; 34% of patients had less than 200/μl and 62.1% less than 400/μl. In patients with clinical AIDS but without HIV antibodies, the mean CD4+ cell level was 807/μl; with 4% below 200/μl and 14.7% below 400/μl. The optimal CD4+ cell cut-off between the two groups of patients (with and without antibody to HIV) was 400/μl. Conclusions: The mean CD4 cell levels of AIDS patients was more than twice the 200 CD4+ cells/μl which, alone or associated with clinical criteria is used to differentiate HIV seropositive patients with and without AIDS. A cut-off of 400 T-lymphocyte equivalents per microlitre (TLE/μl) will be more appropriate. Only 4% of the anti-HIV negative patients had <200 CD4 TLE/μl, and could be infected with unknown immunodeficiency viruses.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Royaume-Uni</li><li>Togo</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Sangare, Affoue" sort="Sangare, Affoue" uniqKey="Sangare A" first="Affoué" last="Sangaré">Affoué Sangaré</name></noCountry><country name="Ghana"><noRegion><name sortKey="Adu Sarkodie, Yaw" sort="Adu Sarkodie, Yaw" uniqKey="Adu Sarkodie Y" first="Yaw" last="Adu-Sarkodie">Yaw Adu-Sarkodie</name></noRegion></country><country name="Togo"><noRegion><name sortKey="D Lmeida, Oscar A" sort="D Lmeida, Oscar A" uniqKey="D Lmeida O" first="Oscar A." last="D Lmeida">Oscar A. D Lmeida</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kanmogne, Georgette D" sort="Kanmogne, Georgette D" uniqKey="Kanmogne G" first="Georgette D." last="Kanmogne">Georgette D. Kanmogne</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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